
%0 Journal Article
%A Allan, RD 
%A Johnston, GAR 
%A Twitchin, B 
%T Synthesis of analogues of GABA. VI. Stereoisomers of <I>cis</I>-3-Aminocyclohexanecarboxylic acid
%J Australian Journal of Chemistry
%D 1981/10/01
%V 34
%N 10
%P 2231-2236
%K 
%R https://doi.org/10.1071/CH9812231
%U https://www.publish.csiro.au/paper/CH9812231 
%X The syntheses are described of (1R,3S)- and (1S,3R)-3-aminocyclohexanecarboxylic acids via unsaturated intermediates suitable for tritium labelling. The absolute stereochemistry was determined by an alternative synthesis of the (1R,3S) isomer from (R)-3-oxocyclohexanecarboxylic acid. The (1S,3R) isomer showed a similar potency to GABA as an inhibitor of the uptake of radioactive GABA by rat brain slices whereas the (1R,3S) isomer was at least 20 times less potent. 
