
TY  - JOUR
A1  - Clezy, PS 
A1  - Fookes, CJR 
T1  - The chemistry of pyrrolic compounds. XLVII. The synthesis of a possible biogenetic precursor of haem <I>a</I> and its relationship to the prosthetic group ofmyeloperoxidase and to cryptoporphyrin <I>a</I>
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1981
VL  - 34
IS  - 4
SP  - 871
EP  - 883
KW  - 
UR  - https://doi.org/10.1071/CH9810871 
N2  - The synthesis of 18-demethyl-18-formylprotoporphyrin dimethyl ester is described and the role of this compound as an intermediate in the biosynthesis of haem a is considered. A possible relationship between a compound of this structure and the prosthetic group of myeloperoxidase is discussed. The cryptoporphyrin a fraction of ox heart extracts has been reexamined and shown to consist of a mixture of Spirographis porphyrin and its isomer which presumably arise from the in vitro oxidation of the vinyl groups in protoporphyrin. 
ER  -

