
%0 Journal Article
%A Hutchison, GI 
%A Prager, RH 
%A Ward, AD 
%T Central nervous system active compounds. III. The synthesis of 4- and 6-substituted caprolactam derivatives by the Schmidt and Beckmann rearrangements
%J Australian Journal of Chemistry
%D 1980/11/01
%V 33
%N 11
%P 2477-2486
%K 
%R https://doi.org/10.1071/CH9802477
%U https://www.publish.csiro.au/paper/CH9802477 
%X The synthesis is described of hexahydroazepin-2-ones (caprolactams) bearing 1-4 alkyl or aryl groups at C4 and C6 by the Beckmann or Schmidt reactions on the corresponding cyclohex-2-enone. Further evidence for the mechanism of the Beckmann rearrangement of these unsaturated oximes is advanced. The central nervous system activity of the alkylated caprolactams is reported. 
