
TY  - JOUR
A1  - Margetson, SA 
A1  - Moore, WJ 
T1  - N.M.R. studies on myelin basic protein. IV. <sup>13</sup>C N.M.R. of the peptide encephalitogenic in the guinea pig
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1980
VL  - 33
IS  - 11
SP  - 2411
EP  - 2425
KW  - 
UR  - https://doi.org/10.1071/CH9802411 
N2  - The encephalitogenic nonapeptide Phe1-Ser2-Trp3-Gly4-Ala5-Glu6-Gly7-Gln8- Lys9 and its [D-Ala5] analogue have been studied in aqueous solution by 13C n.m.r. spectroscopy. The resonances of all the carbons have been assigned and their pH profiles measured. The expected conformational differences are indicated by only subtle differences in long-range pH titration shifts. The spin-lattice relaxation times T1 of all the protonated carbons of the [L-Ala5] nonapeptide have been measured at 25&#176;C. Analysis of these data in terms of effective correlation times for side-chain mobilities suggests restricted motions for the side chains of Glu6 and Gln8 and the aromatic rings of Phe1 and Trp3. 
ER  -

