
%0 Journal Article
%A Bergmann, F 
%A Brown, DJ 
%T Methylation of Purin-8-ones
%J Australian Journal of Chemistry
%D 1979/04/01
%V 32
%N 4
%P 859-865
%K 
%R https://doi.org/10.1071/CH9790859
%U https://www.publish.csiro.au/paper/CH9790859 
%X In general, electrophilic alkylation of purin-8-ones takes place at the same sites as protonation. Exceptions are observed only for 3-methyl derivatives, in which cation formation involves N9, whereas methylation proceeds both at position 1 and 9. This dichotomy of alkylation is ascribed to steric interference between 3- and 9-methyl substituents. 
