
TY  - JOUR
A1  - Brown, DJ 
A1  - Danckwerts, L 
A1  - Grigg, GW 
A1  - Iwai, Y 
T1  - Purine Analogues as Amplifiers of Phleomycin. IV. Some Pyrazolo[3,4-d]pyrimidine, Imidazo[4,5-b]-pyridine, Imidazo[4,5-c]pyridine and Quinazoline Derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1979
VL  - 32
IS  - 2
SP  - 453
EP  - 458
KW  - 
UR  - https://doi.org/10.1071/CH9790453 
N2  - 1-Methyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-thione (1b), its 1-phenyl analogue (1c), 1H-pyrazolo- [3,4-dlpyrimidine-4,6(5H,7H)-dithione (2a), its 1-methyl (2b) and 1-phenyl (2c) derivatives, 1H-imidazo[4,5-b and 4,5-clpyridine-2(3H)-thiones (5) and (6), and quinazoline-4(3H)-thione (9) react with simple alkyl halides, 2-chloroacetamide, 2-chloro-N-methylacetamide or 2-bromopropionamide to give the corresponding thioethers (3e-n), (4a-1), (7a-c), (8a-d) and (10). The unmethylated amides among these show dual NH peaks in their n.m.r. spectra. Activities as amplifiers of phleomycin against E. coli are tabulated and discussed. 
ER  -

