
TY  - JOUR
A1  - Crumbie, RL 
A1  - Deol, BS 
A1  - Nemorin, JE 
A1  - Ridley, DD 
T1  - Asymmetric reduction of carbonyl compounds by yeast. IV. Preparation of optically active &#946;-hydroxy sulfides, sulfoxides and sulfones
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1978
VL  - 31
IS  - 9
SP  - 1965
EP  - 1980
KW  - 
UR  - https://doi.org/10.1071/CH9781965 
N2  - Reduction of simple &#946;-keto sulfides, &#946;-keto sulfoxides and P-keto sulfones by an actively fermenting mutant of Saccharomyces cerevisiae proceeds readily and affords good yields of the corresponding optically active secondary alcohols. For example, 1-(benzylthio)propan-2-one gave optically pure (S)-(+)-1-(benzylthio)propan-2-ol and 1- (phenylsulfonyl)propan-2-one gave optically pure (S)-(+)-1- (phenylsulfonyl)propan-2-ol. In the reductions of racemic &#946;-keto sulfoxides the enantiomers were reduced at sufficiently different rates to enable isolation of an optically active ketone and of an optically active &#946;-hydroxy sulfoxide. Hence, 1-(phenylsulfinyl)propan-2-one gave (S)-(-)-1-(phenyl-sulfinyl)propan-2-one and (RS,SC)-(+)-1- (phenylsulfinyl)propan-2-ol. 
ER  -

