
TY  - JOUR
A1  - Freeman, CG 
A1  - Turner, JV 
A1  - Ward, AD 
T1  - The synthesis and preliminary biological testing of some bicyclic guanidine derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1978
VL  - 31
IS  - 1
SP  - 179
EP  - 186
KW  - 
UR  - https://doi.org/10.1071/CH9780179 
N2  - Condensation of 2-amino-2-imidazoline with &#945;,&#946;-unsaturated esters yields an imidazo[1,2-a]pyrimidin-7-one system whereas reaction with an acetylenic ester or &#946;-keto esters gives the corresponding unsaturated imidazo[1,2-a]pyrimidin-5-one product. In some cases a non-cyclized product is obtained under milder reaction conditions. Cyclization of &#969;- (imidazolin-2-ylamino) acids yields fused bicyclic products for the acetic and propionic acid derivatives whereas the butyric acid analogue cyclizes to yield an N-substituted pyrrolidone. Representative examples of all these compounds do not show mutagenic properties in a modified Ames test and are mainly inactive when tested for central nervous system activity. 
ER  -

