
TY  - JOUR
A1  - Holden, JW 
A1  - Main, L 
T1  - The kinetics and mechanism of the oxidation of mercaptoethanol by riboflavin
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1977
VL  - 30
IS  - 6
SP  - 1387
EP  - 1391
KW  - 
UR  - https://doi.org/10.1071/CH9771387 
N2  - Kinetic study of the oxidation of mercaptoethanol (RSH) by riboflavin (FlH) over the pH range 8.5-10.5 establishes that the rate is given by the term 0.036[FlH][RSH][RS-]]2 mol-2 s-1, there being no buffer catalysis. Any reactivity of the N 3-ionized riboflavin species (Fl-) is sufficiently low to be kinetically undetected. The kinetic form and lack of general acid catalysis are consistent with a nucleophilic (thiolate) 4a-addition-elimination mechanism previously proposed, but a possible alternative mechanism involving a flavin semiquinone (radical) intermediate is suggested. 
ER  -

