
TY  - JOUR
A1  - Brown, DJ 
A1  - Waring, P 
T1  - Simple pyrimidines. XVI. A synthetic route to some 2-(Pyrimidin-2'-yl)acetic acids and esters
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1977
VL  - 30
IS  - 3
SP  - 621
EP  - 627
KW  - 
UR  - https://doi.org/10.1071/CH9770621 
N2  - A general route to the hitherto inaccessible 2-(pyrimidin-2?-yl)acetic acid (3a), its 4?-substituted derivatives, and their esters is described. For example, amidinoacetamide (1; R1 = R2 = NH2) and ethyl benzoylacetate (2; R = Ph) give 2-(4?-hydroxy-6?-phenylpyrimidin-2?- yl)acetamide (3m) which with phosphoryl chloride gives 2-(4?-chloro-6?- phenylpyrimidin-2?-yl)acetonitrile (3n). The nitrile is converted into the corresponding imidic ester (3o) and thence into the carboxylic ester (3p) which undergoes dehalogenation to methyl 2-(4?- phenylpyrimidin-2?-yl)acetate (3q) and subsequent hydrolysis to 2-(4?- phenylpyrimidinyl)acetic acid (3r). 
ER  -

