
TY  - JOUR
A1  - Deol, BS 
A1  - Ridley, DD 
A1  - Simpson, GW 
T1  - Asymmetric reductinon of carbonyl compounds by yeast. II. Preparation of optically active &#945;- and &#946;-hydroxy carboxylic acid derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1976
VL  - 29
IS  - 11
SP  - 2459
EP  - 2467
KW  - 
UR  - https://doi.org/10.1071/CH9762459 
N2  - &#945;- and &#946;-Keto esters and amides are readily reduced by an actively fermenting mutant of Saccharomyces cerevisiae and produce optically active &#945;- and &#946;-hydroxy esters and amides in moderate yields. Typically, methyl 2-oxo-2-phenylacetate gave methyl (R)-(-)-2-hydroxy- 2-phenyl- acetate; 2-oxo-2-phenylacetamide gave (R)-(-)-2-hydroxy-2- phenylacetamide; ethyl benzoylacetate gave ethyl (S)-(-)-3-hydroxy-3- phenylpropionate, and ethyl 2-oxocyclohexanecarboxylate gave ethyl (1R,2S)-(+)-2-hydroxycyclohexanecarboxylate. In each case, the product obtained was optically pure. However, the reduction of ethyl pyruvate to ethyl lactate produced partially racemized products. 
ER  -

