
TY  - JOUR
A1  - Clark-Lewis, JW 
A1  - Tucker, PG 
T1  - Some reactions of 2'-benzyloxychalcone derivatives and preparation of <I>trans</I>-3-Hydroxy-7,4'-dimethoxyflavanone from a chalcone epoxide
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1976
VL  - 29
IS  - 6
SP  - 1397
EP  - 1400
KW  - 
UR  - https://doi.org/10.1071/CH9761397 
N2  - Treating 2'-(4-methoxybenzyl)-4,4'-dimethoxychalcone epoxide with hydrochloric acid in acetic acid gave trans-3-hydroxy-7,4'-dimethoxyflavanone (18%), the first dihydroflavonol with a 4'-methoxylsubstituent obtained by this route. This observation indicates the possibility that replacing the 2'-(4-methoxybenzyl) protecting group in the chalcone by one with more powerful electron-releasing substituents could lead to an acceptable synthesis of dihydroflavonols. 
ER  -

