
%0 Journal Article
%A Clark-Lewis, JW 
%A Tucker, PG 
%T Some reactions of 2'-benzyloxychalcone derivatives and preparation of <I>trans</I>-3-Hydroxy-7,4'-dimethoxyflavanone from a chalcone epoxide
%J Australian Journal of Chemistry
%D 1976/06/01
%V 29
%N 6
%P 1397-1400
%K 
%R https://doi.org/10.1071/CH9761397
%U https://www.publish.csiro.au/paper/CH9761397 
%X Treating 2'-(4-methoxybenzyl)-4,4'-dimethoxychalcone epoxide with hydrochloric acid in acetic acid gave trans-3-hydroxy-7,4'-dimethoxyflavanone (18%), the first dihydroflavonol with a 4'-methoxylsubstituent obtained by this route. This observation indicates the possibility that replacing the 2'-(4-methoxybenzyl) protecting group in the chalcone by one with more powerful electron-releasing substituents could lead to an acceptable synthesis of dihydroflavonols. 
