
%0 Journal Article
%A Bhushan, K 
%A Brown, DJ 
%A Lister, JH 
%A Stephanson, LG 
%A Yoneda, F 
%T Purine studies. XVII. The synthesis of 2-substituted 6,9-Di- and 6,8,9-Tri-methylpurines as amplifiers of phleomycin
%J Australian Journal of Chemistry
%D 1975/11/01
%V 28
%N 11
%P 2553-2559
%K 
%R https://doi.org/10.1071/CH9752553
%U https://www.publish.csiro.au/paper/CH9752553 
%X 2-(6?,8?,9?-Trimethylpurin-2?-ylthio)acetamide (1e) and analogous N- substituted acetamides are prepared by treatment of 6,8,9- trimethylpurine-2-thione (3a) with an appropriate 2- chloroacetamide. 6,9-Dimethyl-2-(piperidin-1?-yl)purine (In) and some 2- polymethyleneamino homologues are made by initial amination of 2- chloro-4-methyl-6-methylamino-5-nitropyrimidine (2b) followed by reduction of the nitro group and final cyclization with formic acid. Such purines enhance the lethal effect of phleomycin on Escherichia coli cultures. 
