
TY  - JOUR
A1  - Boulton, BE 
A1  - Coller, BAW 
T1  - Kinetics, stoichiometry and mechanism in the bromination of aromatic heterocycles. IV. Aqueous bromination of Imidazo[1,2-a]pyridine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1974
VL  - 27
IS  - 11
SP  - 2349
EP  - 2351
KW  - 
UR  - https://doi.org/10.1071/CH9742349 
N2  - The reaction of imidazo[l,2-a]pyridine with bromine has been studied in dilute acidic aqueous solution at 25ºC. The bimolecular rate coefficient for attack by Br2 on the molecular substrate at the 3-position is found to be     Kºbi = 1.30(± 0.05) x 109 dm3 mol-l s-l  We find pK.(imidazo[l,2-a]pyridine-H+, aq., 25ºC) = 6.65 and pK,(3-bromoimidazo[l,2-alpyridine-H+, aq.,25ºC) = 4.95. The latter compound reacts with bromine in aqueous acetate buffer at pH4. 
ER  -

