
%0 Journal Article
%A Boulton, BE 
%A Coller, BAW 
%T Kinetics, stoichiometry and mechanism in the bromination of aromatic heterocycles. IV. Aqueous bromination of Imidazo[1,2-a]pyridine
%J Australian Journal of Chemistry
%D 1974/11/01
%V 27
%N 11
%P 2349-2351
%K 
%R https://doi.org/10.1071/CH9742349
%U https://www.publish.csiro.au/paper/CH9742349 
%X The reaction of imidazo[l,2-a]pyridine with bromine has been studied in dilute acidic aqueous solution at 25ºC. The bimolecular rate coefficient for attack by Br2 on the molecular substrate at the 3-position is found to be     Kºbi = 1.30(± 0.05) x 109 dm3 mol-l s-l  We find pK.(imidazo[l,2-a]pyridine-H+, aq., 25ºC) = 6.65 and pK,(3-bromoimidazo[l,2-alpyridine-H+, aq.,25ºC) = 4.95. The latter compound reacts with bromine in aqueous acetate buffer at pH4. 
