
TY  - JOUR
A1  - Brown, DJ 
A1  - Waring, P 
T1  - Simple pyrimidines. XV. The synthesis, piperidinolysis and hydrolysis of simple 2- and 4-(Halogenomethyl)pyrimidines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1974
VL  - 27
IS  - 10
SP  - 2251
EP  - 2259
KW  - 
UR  - https://doi.org/10.1071/CH9742251 
N2  - The 2-and 4-bromomethyl-, dibromomethyl- and (impure) tribromomethyl-pyrimidines, as well as their chloro analogues, were made by direct halogenation of 2- or 4-methylpyrimidine (3m) and (3e) with the appropriate N-halogenosuccinimide. Rates were measured spectrometrically for piperidinolysis and alkaline hydrolysis of the monohalogenomethylpyrimidines which reacted much more rapidly than 2- and 4-halogenopyrimidines. 4,6-Dimethylpyrimidin-2-ylmethanol and 2,6-dimethyl- pyrimidin-4-ylmethanol were made by reduction of the corresponding esters (1 and 2; R = CO2Et). The u.v., n.m.r, and mass spectra of the compounds are discussed. 
ER  -

