
TY  - JOUR
A1  - Brown, DJ 
A1  - Stephanson, LG 
T1  - Purine studies. XIII. The metabolism of 2,9-Dimethyl-8-methylthiopurine and 2-Carbamoylmethylthio-6,9-dimethylpurine in mice
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1974
VL  - 27
IS  - 6
SP  - 1371
EP  - 1375
KW  - 
UR  - https://doi.org/10.1071/CH9741371 
N2  - The metabolism of two purines, which enhance the antibiotic activity of phleomycin in vitro, has been followed in mice. 2,9-Dimethyl-8-methylthiopurine (1c) gave mainly 2,9-dimethyl-8-methylthiopurin-6-one (2; R = SMe) and the corresponding sulphoxide (2; R = SOMe). In contrast, 2-carbamoylmethylthio-6,9-dimethylpurine (1d) gave 2-carbamoylmethylthio-6,9-dimethylpurin-8-one (5; R1 = SCH2CONH2, R2 = Me) accompanied in the urine by unchanged material (1d). The identity of each metabolite was confirmed by unambiguous synthesis. 
ER  -

