
%0 Journal Article
%A Brown, DJ 
%A Stephanson, LG 
%T Purine studies. XIII. The metabolism of 2,9-Dimethyl-8-methylthiopurine and 2-Carbamoylmethylthio-6,9-dimethylpurine in mice
%J Australian Journal of Chemistry
%D 1974/06/01
%V 27
%N 6
%P 1371-1375
%K 
%R https://doi.org/10.1071/CH9741371
%U https://www.publish.csiro.au/paper/CH9741371 
%X The metabolism of two purines, which enhance the antibiotic activity of phleomycin in vitro, has been followed in mice. 2,9-Dimethyl-8-methylthiopurine (1c) gave mainly 2,9-dimethyl-8-methylthiopurin-6-one (2; R = SMe) and the corresponding sulphoxide (2; R = SOMe). In contrast, 2-carbamoylmethylthio-6,9-dimethylpurine (1d) gave 2-carbamoylmethylthio-6,9-dimethylpurin-8-one (5; R1 = SCH2CONH2, R2 = Me) accompanied in the urine by unchanged material (1d). The identity of each metabolite was confirmed by unambiguous synthesis. 
