
TY  - JOUR
A1  - Brown, DJ 
A1  - Waring, P 
T1  - Pyrimidine reactions. XXIV. The dehalogenation of 2-halogenopyrimidines by hydriodic acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1973
VL  - 26
IS  - 2
SP  - 443
EP  - 447
KW  - 
UR  - https://doi.org/10.1071/CH9730443 
N2  - 2-Halogenopyrimidines underwent dehalogenation conveniently on treatment with hot hydriodic acid; 4,6-dimethyl-, 4,6-diphenyl-, 5- methyl-, 4-methyl-, and 4-amino-pyrimidine were so prepared from their respective 2-chloro derivatives, of which the second and third were made by improved methods; unsubstituted pyrimidine was obtained similarly from its 2-chloro, 2-bromo, or 2-iodo derivative, of which the last was made in a pure state for the first time. In contrast, 4- chloro-2,6-dimethylpyrimidine underwent hydrolysis in hot hydriodic acid and transhalogenation to give its 4-iodo analogue at lower temperatures; both 2-chloro-4-methoxy-pyrimidine and 5-chlorouracil gave uracil with hot hydriodic acid; and 4-chloro- 2,6- dimethoxypyrimidine gave 6-iodouracil under similar conditions. 
ER  -

