
TY  - JOUR
A1  - Maynard, JA 
A1  - Rae, ID 
A1  - Rash, D 
A1  - Swan, JM 
T1  - Reaction of 2-(4'-Thiazolyl)benzimidazole (thiabendazole) with alkyl halides
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1971
VL  - 24
IS  - 9
SP  - 1873
EP  - 1881
KW  - 
UR  - https://doi.org/10.1071/CH9711873 
N2  - 2-(4?-Thiazolyl)benzimidazole (thiabendazole) is alkylated at a benzimidazole nitrogen by reaction with sodium hydride and an alkyl halide. With 1,3-dibromo-propane and 1,2-dibromoethane, the thiazole nitrogen is also alkylated to give quaternary salts containing the 6,7- dihydro-5H-thiazolo[3?,4?:1.2][1,4]diazepino-[8,9-a]benzimidazole and 5,6-dihydrothiazolo[3?,4?:1,2]pyrazino[7,8-a]benzimidazole ring systems respectively. The structures proposed for these tetracyclic products are supported by spectroscopic examination of the products formed by alkali fission of their thiazole rings. 
ER  -

