
TY  - JOUR
A1  - Birch, AJ 
A1  - Gager, F 
A1  - Mo, L 
A1  - Pelter, A 
A1  - Wright, JJ 
T1  - Studies in relation to biosynthesis. XLI. Canescin
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1969
VL  - 22
IS  - 11
SP  - 2429
EP  - 2436
KW  - 
UR  - https://doi.org/10.1071/CH9692429 
N2  - The biosynthesis of canescin (I) has been investigated. The isocoumarin portion is derived from a polyketide chain. One carbon atom of the &#947;- lactone ring and the carbon atom of the methoxyl group originate from methionine whilst the other three carbon atoms of the &#947;-lactone have a symmetrical C4-acid of the citric acid cycle as their precursor. This metabolite is most unusual in that an oxygenated methionine-derived carbon atom provides the growing point of a new carbon chain. A possible mechanism for the attachment of the lactone is suggested. 
ER  -

