
TY  - JOUR
A1  - Bolton, PD 
A1  - Jackson, GL 
T1  - Hydrolysis of amides. III. Dilute acid hydrolysis of amides of the type R-CH<sub>2</sub>-CONH<sub>2</sub>
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1969
VL  - 22
IS  - 3
SP  - 527
EP  - 532
KW  - 
UR  - https://doi.org/10.1071/CH9690527 
N2  - Rate constants over a range of temperature, enthalpies of activation, and entropies of activation are reported for the dilute acid hydrolysis of n-valeramide, isovaleramide, 3,3-dimethylbutanamide, phenylacetamide, cyclohexylacetamide, methoxyacetamide, bromoacetamide, and chloroacetamide.     The rate constants of the first six amides together with those of two other alkyl-substituted acetamides taken from a previous paper are almost perfectly correlated by the Taft linear steric energy relationship. The enthalpies of activation, also, show a linear dependence on the steric parameter, Es. The results obtained for the halogeno amides indicate that the acid hydrolysis of amides may show a slight sensitivity to polar effects. 
ER  -

