
TY  - JOUR
A1  - Hearn, MTW 
A1  - Ward, AD 
T1  - Hydroxamic acids. II. The acetylation of O-alkylhydroxamic acids
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1969
VL  - 22
IS  - 1
SP  - 161
EP  - 173
KW  - 
UR  - https://doi.org/10.1071/CH9690161 
N2  - O-Alkylhydroxamic acids are readily acetylated, in high yield, under mild conditions. Aliphatic O-alkylhydroxamic acids yield only one product, shown to be the N-acetyl derivative. O-Alkylarylhydroxamic acids form both the O- and N- acetyl isomers; the ratio of these isomers depends on electronic and steric effects. Ultraviolet spectral data indicate that the salts of O-alkylarylhydroxamic acids exist predominantly in the hydroximic acid form; however, it is not possible to decide which is the acidic proton of the hydroxamic acid system. The nature of the cation in the salts of O-alkylhydroxamic acids is important in determining the site of acetylation. 
ER  -

