
TY  - JOUR
A1  - Baklien, A 
A1  - Leeding, MVKJ 
T1  - A new synthesis of tetramisole hydrochloride, (&#176;)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1- b]thiazole hydrochloride
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1968
VL  - 21
IS  - 6
SP  - 1557
EP  - 1570
KW  - 
UR  - https://doi.org/10.1071/CH9681557 
N2  - Tetramisole hydrochloride, a potent anthelmintic, has now been synthesized by condensation of styrene oxide and ethylenimine. The product, 1-(P-hydroxy-phenethyl)aziridine, reacts with thiourea or thiocyanic acid to yield 3-(P-hydroxy-phenethyl)-2-iminothiazolidine. Following chlorination with thionyl chloride, a base-catalysed cyclization gives tetramisole. The method provides a general route to 2,3,5,6-tetrahydroimidazo[2,l-b]thiazoles. 
ER  -

