
%0 Journal Article
%A Baklien, A 
%A Leeding, MVKJ 
%T A new synthesis of tetramisole hydrochloride, (&#176;)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1- b]thiazole hydrochloride
%J Australian Journal of Chemistry
%D 1968/06/01
%V 21
%N 6
%P 1557-1570
%K 
%R https://doi.org/10.1071/CH9681557
%U https://www.publish.csiro.au/paper/CH9681557 
%X Tetramisole hydrochloride, a potent anthelmintic, has now been synthesized by condensation of styrene oxide and ethylenimine. The product, 1-(P-hydroxy-phenethyl)aziridine, reacts with thiourea or thiocyanic acid to yield 3-(P-hydroxy-phenethyl)-2-iminothiazolidine. Following chlorination with thionyl chloride, a base-catalysed cyclization gives tetramisole. The method provides a general route to 2,3,5,6-tetrahydroimidazo[2,l-b]thiazoles. 
