
TY  - JOUR
A1  - Hay, RW 
A1  - Bond, MA 
T1  - Kinetics of the Decarboxylation of Acetoacetic acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1967
VL  - 20
IS  - 9
SP  - 1823
EP  - 1828
KW  - 
UR  - https://doi.org/10.1071/CH9671823 
N2  - The decarboxylation of acetoacetic acid CH3COCH2CO2H &#8594; CH3COCH3+CO2 and its anion have been studied in aqueous solution over a range of temperature. Although the acid decomposes approximately 50 times faster than the anion at 37°, the activation energy of the acid (23.7 kcal mole-1) is comparable with that of the anion (22.9 kcal mole-1) and the large difference in reactivity is due to an entropy effect. The significance of these results is discussed and a comparison made with other &#946;-keto acid decarboxylations. 
ER  -

