
%0 Journal Article
%A Hudson, CB 
%A Robertson, AV 
%T Reactions of 3,4-dehydroproline and 4-chloroprolines with ninhydrin, isatin, and cyclic &#945;-diketones
%J Australian Journal of Chemistry
%D 1967/07/01
%V 20
%N 7
%P 1511-1520
%K 
%R https://doi.org/10.1071/CH9671511
%U https://www.publish.csiro.au/paper/CH9671511 
%X 3,4-Dehydro-DL-proline reacts with a number of a-dicarbonyl compounds to form products in which the pyrroline ring is converted into an N- substituted pyrrole. Depending on the reactivity of the &#945;-dicarbonyl compound, a second molecule may (e.g. ninhydrin) or may not (e.g, isatin) react further by &#945;-substitution of the pyrrole. The structures of the products account for the different colour reactions of dehydroproline compared with proline. cis- and trans-4-Chloro-L-proline yield the same products as dehydroproline with ninhydrin and isatin. 
