
TY  - JOUR
A1  - Johns, SR 
A1  - Lamberton, JA 
A1  - Sioumis, AA 
T1  - <I>Cassytha</I> alkaloids. III. Aporphine alkaloids from <I>Cassytha melantha</I> R. Br
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1966
VL  - 19
IS  - 12
SP  - 2339
EP  - 2345
KW  - 
UR  - https://doi.org/10.1071/CH9662339 
N2  - The major alkaloid of Cassytha melantha R.Br, and Cassytha glabella R.Br. is (+)-9-hydroxy-10-methoxy-1,2-methylenedioxyaporphine (cassythicine), which has not been previously found to occur naturally, although the (±)-form has been synthesized by Tomita and Kikkawa. A minor alkaloid from C. melantha, isolated only in the form of an NO- diacetyl derivative, appears to be the noraporphine corresponding to cassythicine and it is presumably identical with the known alkaloid actinodaphnine.   A study has been made of the N.M.R. spectra of a number of N- acetyl-N-methylaminoethylphenanthrenes, obtained from aporphines by heating with acetic anhydride. These show not only the expected splitting of the N-methyl and N-acetyl signals due to cis-trans isomerism of the amide group, but also a long-range splitting of the signals from certain aryl protons. 
ER  -

