
TY  - JOUR
A1  - Clark-Lewis, JW 
A1  - Jemison, RW 
T1  - The absolute configurations of (&#8211;)-angolensin and some related 1,2-diarylpropanes
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1965
VL  - 18
IS  - 11
SP  - 1791
EP  - 1797
KW  - 
UR  - https://doi.org/10.1071/CH9651791 
N2  - (-)-Angolensin has been converted into (+)-(2S)-1-(2,4-dimethoxyphenyl)-2-(4-methoxyphenyl)propane, an analogue of (+)-(2S)-1-(2,4,6-trimethoxyphenyl)-2-(3,4-dimethoxyphenyl)propane. The stereochemistry of angolensin is thereby correlated with that of catechin and epicatechin. Oxidation of (+)-(2S)-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)propane gave (+)-3-(4-methoxyphenyl)- butyric acid, in agreement with the established absolute configuration of (-)-angolensin. The (+)-butyric acid was also prepared by resolution of the synthetic racemate with quinine, and by homologation of (-)-2-(4-methoxyphenyl)propionic acid. 
ER  -

