
TY  - JOUR
A1  - Grant, IJ 
A1  - Hay, RW 
T1  - Copper(II) catalysis of the hydrolysis of glycylglycine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1965
VL  - 18
IS  - 8
SP  - 1189
EP  - 1195
KW  - 
UR  - https://doi.org/10.1071/CH9651189 
N2  - Copper(II) ions catalyse the hydrolysis of glycylglycine in the pH range 3.5-6. The pH-rate profile has a maximum at pH 4.2, due to the formation of a complex CuGlyGly+. The decrease in rate at higher pH values is associated with the production of catalytically inactive CuGlyGly complexes produced by the ionization of the peptide hydrogen atom. The mechanism of the reaction is discussed and its possible biological significance considered. 
ER  -

