
TY  - JOUR
A1  - Crow, WD 
A1  - Michael, M 
T1  - Alkaloids of the Australian Apocynaceae: <I>Kopsia longiflora</I> Merr. III. Preliminary Degradation of the Alkaloids
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1962
VL  - 15
IS  - 1
SP  - 130
EP  - 138
KW  - 
UR  - https://doi.org/10.1071/CH9620130 
N2  - Graded alkaline hydrolysis of the monoacid tertiary bases kopsiflorine (C23H28O5N2), kopsilongine (C24H30O6N2), and kopsamine (C24H28O7N2) shows that they contain two methoxycarbonyl groups. All but one of the residual oxygen atoms are accounted for as aromatic ether linkages. One of the methoxycarbonyl groups is responsible for the deactivation of the other nitrogen atom (N(a)) present, since anew basic centre is generated by partial hydrolysis and subsequent decarboxylation of the acid produced. The alkaloids are tentatively formulated as blocked indoline bases containing a urethane grouping at N(a). The fourth alkaloid, kopsinine (C21H26O2N2) is similarly formulated, but in this case N(a) is weakly basic, the urethane methoxycarbonyl group and the additional oxygen atom being absent. 
ER  -

