
TY  - JOUR
A1  - Tietze, Lutz F. 
A1  - Lücke, Lars P. 
A1  - Major, Felix 
A1  - Müller, Peter 
T1  - Efficient Synthesis of an Enantiopure Thiasteroid by a Double Heck Reaction
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2004
VL  - 57
IS  - 7
SP  - 635
EP  - 640
KW  - 
UR  - https://doi.org/10.1071/CH04034 
N2  - The thiaestrane 7 was synthesized by two sequential Heck reactions starting from the thiophene derivatives 8a&#8211;8c, which contain a (Z)-halogenovinyl group, and the enantiopure hydrindene 2a. The first intermolecular Pd-catalyzed reaction leads to 11a and 11b in a highly regio- and diastereoselective manner. A subsequent intramolecular Heck reaction catalyzed by the palladacycle 4 then gave the thiasteroid 7 with an unusual cis-junction of the rings B and C. 
ER  -

