
TY  - JOUR
A1  - Parsons, Lisa 
A1  - Liu, Fang 
A1  - Yeh, Deok Cheon 
A1  - Sari, Nese 
A1  - Orban, John 
T1  - Integrating Structural and Functional Genomics
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2004
VL  - 57
IS  - 7
SP  - 619
EP  - 623
KW  - 
UR  - https://doi.org/10.1071/CH04024 
N2  - Structural genomics has provided many three-dimensional structures of proteins with unknown or poorly defined function where analysis of the fold suggests a possible binding site for small molecules. An approximate function may be evident from the structure but, most often, the specific target ligand remains unknown. This is a widespread observation in structural genomics programs and demonstrates the limits of structure-based approaches to determining function. Methods to identify the natural target ligands for such proteins, and therefore bridge structural and functional genomics studies, are discussed. 
ER  -

