
%0 Journal Article
%A Parsons, Lisa 
%A Liu, Fang 
%A Yeh, Deok Cheon 
%A Sari, Nese 
%A Orban, John 
%T Integrating Structural and Functional Genomics
%J Australian Journal of Chemistry
%D 2004/07/07
%V 57
%N 7
%P 619-623
%K 
%R https://doi.org/10.1071/CH04024
%U https://www.publish.csiro.au/paper/CH04024 
%X Structural genomics has provided many three-dimensional structures of proteins with unknown or poorly defined function where analysis of the fold suggests a possible binding site for small molecules. An approximate function may be evident from the structure but, most often, the specific target ligand remains unknown. This is a widespread observation in structural genomics programs and demonstrates the limits of structure-based approaches to determining function. Methods to identify the natural target ligands for such proteins, and therefore bridge structural and functional genomics studies, are discussed. 
