
TY  - JOUR
A1  - Gunatillake, Pathiraja A. 
A1  - Martin, Darren J. 
A1  - Meijs, Gordon F. 
A1  - McCarthy, Simon J. 
A1  - Adhikari, Raju 
T1  - Designing Biostable Polyurethane Elastomers for Biomedical Implants
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2003
VL  - 56
IS  - 6
SP  - 545
EP  - 557
KW  - 
UR  - https://doi.org/10.1071/CH02168 
N2  - The chemical structure, synthesis, morphology, and properties of polyurethane elastomers are briefly discussed. The current understanding of the effect of chemical structure and the associated morphology on the stability of polyurethanes in the biological environments is reviewed. The degradation of conventional polyurethanes appears as surface or deep cracking, stiffening, and deterioration of mechanical properties, such as flex-fatigue resistance. Polyester and poly(tetramethylene oxide) based polyurethanes degrade by hydrolytic and oxidative degradation of ester and ether functional groups, respectively. The recent approaches to develop polyurethanes with improved long-term biostability are based on developing novel polyether, hydrocarbon, polycarbonate, and siloxane macrodiols to replace degradation-prone polyester and polyether macrodiols in polyurethane formulations. The new approaches are discussed with respect to synthesis, properties and biostability based on reported in vivo studies. Among the newly developed materials, siloxane-based polyurethanes have exhibited excellent biostability and are expected to find many applications in biomedical implants. 
ER  -

