
TY  - JOUR
A1  - Bergmann, David J. 
A1  - Campi, Eva M. 
A1  - Jackson, W. Roy 
A1  - Patti, Antonio F. 
A1  - Saylik, Dilek 
T1  - Synthesis of Medium and Large Cyclic Amines in Rhodium-Catalysed Reactions of Aminoalkenes with H<emph type="8">2</emph>/CO
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2001
VL  - 53
IS  - 10
SP  - 835
EP  - 844
KW  - Cyclic amines; rhodium catalysts; Biphepos.
UR  - https://doi.org/10.1071/CH00112 
N2  - Rhodium-catalysed reactions of N-benzyl- or N-alkyl-aminoalkenes (6) with H2/CO can give cyclic amines (7) (7&#8211;13 ring size) in good to excellent yields when BIPHEPHOS is used as a ligand. Hydrogenation of the aminoalkene becomes a competing reaction for the smaller rings but can be overcome by using a H2/CO gas ratio of 1 : 5. Reactions of 2-alkenyloxybenzylamines (13) gave 9-, 12- and 17-membered rings (14) in 30&#8211;40% yield, but dimer formation (16) and/or hydrogenation were competing reactions. Similar reactions of alkenylamides and ortho-alkenylanilines gave only non-cyclized amino aldehydes as products in low isolated yields. 
ER  -

