
TY  - JOUR
A1  - Polaskova, Martina E. 
A1  - Lambert, John N. 
A1  - Ede, Nicholas J. 
T1  - Synthesis of Nanotubule-Forming Cyclic Octapeptides via an Fmoc Strategy
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1998
VL  - 51
IS  - 7
SP  - 535
EP  - 540
KW  - 
UR  - https://doi.org/10.1071/C98006 
N2  - New syndiotactic cyclic octapeptides, namely cyclo(&#8211;D-Phe-L-Asp&#8211;D-Phe&#8211;L-Asn&#8211;D-Phe&#8211;L-Asp&#8211;D-Phe&#8211;L-Asn&#8211;) (1) and cyclo(&#8211;D-N-MeAla&#8211;L-Asp&#8211;D-N-MeAla&#8211;L-Asn&#8211;D-N-MeAla&#8211;L-Asp&#8211;D-N-MeAla&#8211;L-Asn&#8211;) (2), have been prepared, and preliminary structural studies have been conducted. The synthesis of the linear peptides was performed by using Fmoc chemistry, and head-to-tail cyclization was accomplished by using an orthogonal protection strategy and a support-bound cyclization step. Acidification of aqueous solutions of cyclic octapeptide (1) initiated formation of needlelike crystals whose morphology and infrared absorption behaviour suggested that they were hydrogen-bonded nanotubular aggregates of (1). 
ER  -

