
TY  - JOUR
A1  - Teo, Chih-Lynne 
A1  - Fenton, Ronald R. 
A1  - Turner, Peter 
A1  - Hambley, Trevor W. 
T1  - The Dichloroplatinum(II) Complex of 5,5,7-Trimethyl-1,4-diazacycloheptane: Preparation, Crystal Structure and Binding to Nucleotides and DNA
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1998
VL  - 51
IS  - 11
SP  - 977
EP  - 984
KW  - 
UR  - https://doi.org/10.1071/C97176 
N2  - The preparation of &#91;Pt(tmdz)Cl2&#93; (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) is described. The crystal structure has been determined by X-ray diffraction methods and refined to an R value of 0&#183;048 (764F). The crystals are triclinic, space group P -1, a 8&#183;023(2), b 10&#183;874(4), c 14&#183;207(3) &#197;, &#945; 95&#183;34(3), &#946; 94&#183;96(2), &#947; 94&#183;97(3)&#176;. N.m.r. studies and molecular mechanics methods show that only one diastereomer of the complex&#8212;that observed in the crystal structure&#8212;is energetically accessible. In total DNA binding studies, &#91;Pt(tmdz)Cl2&#93; binds less effectively and at a lower rate than cisplatin. The complex reacts with dG and d(GpG) to form a variety of isomeric products, as indicated by h.p.l.c. analysis. 
ER  -

