
TY  - JOUR
A1  - Yuasa, Yoko 
A1  - Yuasa, Yoshifumi 
A1  - Tsuruta, Haruki 
T1  - The Synthesis of (<emph type="2">S</emph>)-3-Acetylthio-2-benzylpropionic Acid from (<emph type="2">Z</emph>)-2-Chloromethyl-3-phenylprop-2-enoic Acid by Asymmetric Hydrogenation: a Chiral Building Block of an Enkephalinase Inhibitor
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1998
VL  - 51
IS  - 6
SP  - 511
EP  - 514
KW  - 
UR  - https://doi.org/10.1071/C97141 
N2  - (S)-2-Benzyl-3-chloropropionic acid (7) was synthesized from (Z)-2-(chloromethyl)-3-phenylprop-2-enoic acid (5) by asymmetric hydrogenation with a ruthenium 2,2&#8242;-bis(di-p-tolylphosphino)-1,1&#8242;-binaphthyl complex in the presence of triethylamine. Acetylthiolation then gave 3-acetylthio-2-benzylpropionic acid (2), a subunit of the enkephalinase inhibitor thiorphan (1). 
ER  -

