
TY  - JOUR
A1  - Abell, Andrew D. 
A1  - Phillips, Andrew J. 
A1  - Budhia, Sangeeta 
A1  - McNulty, Ann M. 
A1  - Neubauer, Blake L. 
T1  - The Preparation and Biological Activity of Lactam-Based, Non-Steroidal, Inhibitors of Human Type-1 Steroid 5&#945;-Reductase.
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1998
VL  - 51
IS  - 5
SP  - 389
EP  - 396
KW  - 
UR  - https://doi.org/10.1071/C97130 
N2  - A Beckmann rearrangement of cis- and trans-fused 3,4,4a,9,10,10a-hexahydrophenanthren-1(2H)-one oximes has yielded three azepines. An in vitro assay of the azepines and (3aSR,9bSR)-6-methoxy-3-methyl-1,3,3a,4,5,9b-hexahydro-2H-benz&#91;e&#93;indol-2-one, prepared in four steps from naphthalene-1,6-diol, against human type-1 steroid 5&#945;-reductase, revealed the tricyclic five-membered lactam to be a potent inhibitor (IC50 733 nM). 
ER  -

