
TY  - JOUR
A1  - Ahn,, Paul D. 
A1  - Bishop,, Roger 
A1  - Craig, Donald C. 
A1  - Downing, Gary A. 
A1  - Scudder, Marcia L. 
T1  - Systematic Structural Modification of a Pentacyclic Helical Tubuland Host Diol
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1998
VL  - 50
IS  - 11
SP  - 1053
EP  - 1060
KW  - 
UR  - https://doi.org/10.1071/C97073 
N2  - Reaction of methylmagnesium chloride and pentacyclo&#91;7.3.0.0 2,7.0 3,11 .0 6,10 &#93;dodecane-8,12-dione (4) yields the C2-symmetric diol (5) (62%) and the unsymmetrical diol (6) (36%) whose crystal structures are analysed in crystal engineering terms. The former isomer is the tenth member of the helical tubuland diol family, crystallizing in space groupP 3121 as a microporous lattice containing empty parallel canals with 9&#183; 9&#197;2cross-sectional area. Molecules of diol (6) hydrogen bond through (-O-H)4 cycles to form layers which stack in space group P 21/c by means of hydrocarbon dispersion forces. Diol (7), the bis(trifluoromethyl) analogue of (5), does not form a helical tubuland lattice. The structure of its hemihydrate also contains (&#8211;O&#8211;H)4 cycles but here the second diol hydroxy group hydrogen bonds to water resulting in a network structure in space group P-421c. 
ER  -

