
TY  - JOUR
A1  - Hughes, Robert 
A1  - Prager, Rolf H. 
T1  - Potential GABA<emph tye="8">B</emph> Receptor Antagonists. VIII. The Synthesis of 3-Amino-<emph type="2">N</emph>-aryl-2-hydroxy- propane-1-sulfonamides and Analogues of Baclofen Containing Nitro Groups
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 1
SP  - 19
EP  - 26
KW  - 
UR  - https://doi.org/10.1071/C96149 
N2  - 3-Amino-N-aryl-2-hydroxypropane-1-sulfonamides were synthesized by the reaction of the corresponding epoxy sulfonamide with sodium azide, followed by reduction to the corresponding amine. The synthesis of 3-nitropropan-1-amine and two 2-thienyl derivatives is also reported. 3-Amino-2-hydroxy-N-(4-nitrophenyl)propane-1-sulfonamide and 3-nitropropan-1-amine were found to be specific antagonists of GABA at the GABAB receptor. Substitution of the amino group by alkyl or aryl groups reduced the activity. 
ER  -

