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The Future of Retrosynthesis and Synthetic Planning: Algorithmic, Humanistic or the Interplay?

Craig M. Williams https://orcid.org/0000-0002-3834-7398 A B and Madeleine A. Dallaston https://orcid.org/0000-0002-9247-9682 A
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A School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Qld 4072, Australia.

B Corresponding author. Email: c.williams3@uq.edu.au




Craig M. Williams (C.M.W.) was born in Adelaide, Australia. He received his B.Sc. (Hons) degree in chemistry in 1994 from Flinders University. In 1997, he was awarded his Ph.D. in organic chemistry from the same institution under the supervision of Professor Rolf H. Prager. He undertook post-doctoral studies as an Alexander von Humboldt Fellow working with Professor Armin de Meijere at the Georg-August-Universität, Göttingen, Germany, from 1997 to 1999. In early 1999, he accepted a second post-doctoral fellowship at the Australian National University with Professor Lewis N. Mander. Professor Williams has held an academic position at the University of Queensland since 2000, and during this time has won a number of awards including a Thieme Chemistry Journals Award in 2007, an Australian Research Council Future Fellowship award in 2011, and the Award for Outstanding Contribution to Research (SCMB, UQ, 2019). The Williams research group explores numerous interests within the discipline of organic chemistry (e.g. medicinal chemistry, fundamental molecules, natural product isolation, microelectronics, drug and agrichemical development, impact sensitive molecules) enabled by organic synthesis refined through the construction of biologically active complex natural products (diterpenes, polyketides, alkaloids), and designs synthetic methodology to assist in this endeavour (synthetic transformations and reagents). Professor Williams especially enjoys teaching whole molecule retrosynthesis to undergraduate and post-graduate students.



Madeleine A. Dallaston (M.A.D.) was born in Leicester, England, and grew up in Brisbane, Australia. In 2016, she received her B.Sc. from Griffith University, earning the RACI Queensland Branch Prize for that year. In 2017, she undertook a B.Sc. (Hons) at the University of Queensland in collaboration with Defense Science and Technology, working on energetic materials for countermeasures development. She then commenced her Ph.D. in organic chemistry at the University of Queensland under the supervision of Professor Williams and G. Paul Savage in 2018, focusing on the synthesis of novel heterocycles for application as bioisosteres.

Australian Journal of Chemistry 74(5) 291-326 https://doi.org/10.1071/CH20371
Submitted: 21 December 2020  Accepted: 25 March 2021   Published: 12 May 2021



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