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Structural Basis for the Structure–Activity Behaviour of Oxaliplatin and its Enantiomeric Analogues: A Molecular Dynamics Study of Platinum-DNA Intrastrand Crosslink Adducts

Jing Yang A , Jing Chen B D and Zibiao Li C D
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A Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Republic of Singapore.

B Experimental Center, Yunnan University of Traditional Chinese Medicine, Yuhua Road, #1076, Chenggong District, Kunming, Yunnan 650500, China.

C Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #09-52, Singapore 138634, Republic of Singapore.

D Corresponding authors. Email: sunnychenj@163.com; lizb@imre.a-star.edu.sg

Australian Journal of Chemistry 69(4) 379-387 https://doi.org/10.1071/CH15624
Submitted: 6 October 2015  Accepted: 6 November 2015   Published: 25 November 2015



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