Articles citing this paper
Molecular Characterization of Collagen Hydroxylysine O-Glycosylation by Mass Spectrometry: Current Status
Irina Perdivara A C , Mitsuo Yamauchi B and Kenneth B. Tomer A
+ Author Affiliations
- Author Affiliations
A Mass Spectrometry Group, National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, NC 27709, USA.
B School of Dentistry, University of North Carolina at Chapel Hill, North Carolina, NC 27599, USA.
C Corresponding author. Email: perdivarai@niehs.nih.gov
Irina Perdivara received her Diploma in Chemistry (2006) and Ph.D. with Honors in Analytical Biochemistry (2009) from the University of Konstanz, Germany. Her research at NIEHS is focussed on structure determination of proteins involved in aging, autoimmune, neurodegenerative and bone diseases by high-performance liquid chromatography – tandem mass spectrometry. Her major area of interest is characterization of protein glycosylation at the glycopeptide level in raw proteolytic mixtures to understand its functional implications in health and disease. Dr Perdivara has set the foundation for quantitative site-specific collagen glycosylation analysis, which has led to significant progress in the research areas of bone physiology and bone-related diseases.
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Mitsuo Yamauchi received a DDS (1976) and a Ph.D. in Biochemistry (1983) from the Tokyo Medical and Dental University, Tokyo, Japan. During his residency in Oral Surgery at the same university, he started research on collagen and became a post-doctoral fellow in the Dental Research Center at the University of North Carolina (UNC) at Chapel Hill under the late Professor Gerald L. Mechanic (1978–81). He is currently Sunstar Distinguished Professor of Oral Biology and Professor of Periodontology at UNC at Chapel Hill. His research interests include the biology and chemistry of collagen post-translational modifications, biological functions of matrix proteins in mineralization and aging, and bone-tissue engineering.
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Dr. Tomer's research has focussed on characterization of biomolecules involved in immunological and inflammatory responses to environmental exposure. In over 300 research articles, he has reported the development and application of new techniques – nanoflow capillary LC, direct analysis of affinity-bound analytes by MALDI-MS, on-line microdialysis-MS-MS and on-line capillary electrophoresis-MS – and major applications – protein sequences, PTMs, protein structures, epitope mapping, and small-molecule quantitation. Dr Tomer retired at the end of 2011, but remains actively engaged in mass spectrometry at NIEHS, and in the continued mentoring of Fellows as they transition to the next stage in their careers.
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Australian Journal of Chemistry 66(7) 760-769 https://doi.org/10.1071/CH13174
Submitted: 11 April 2013 Accepted: 4 May 2013 Published: 18 July 2013
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