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Chemical Modifications on 4-Arylpiperazine-Ethyl Carboxamide Derivatives Differentially Modulate Affinity for 5-HT1A, D4.2, and α 2A Receptors: Synthesis and In Vitro Radioligand Binding Studies

Amaury Graulich A , Marc Léonard A , Mélissa Résimont A , Xi-Ping Huang B , Bryan L. Roth B and Jean-François Liégeois A C
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A Drug Research Center, Laboratory of Medicinal Chemistry, University of Liège, Avenue de l’Hôpital 1 (B36), B-4000 Liège 1, Belgium.

B Department of Pharmacology, School of Medicine and Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina Chapel Hill Medical School, 4072 Genetic Medicine Building, CB 7365, Chapel Hill, NC 27599, USA.

C Corresponding author. Email: JF.Liegeois@ulg.ac.be

Australian Journal of Chemistry 63(1) 56-67 https://doi.org/10.1071/CH09353
Submitted: 20 June 2009  Accepted: 13 August 2009   Published: 8 January 2010



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