Chiral 2 α,4-Dihydroxy-1,8-cineole as a Possum Urinary Metabolite

Abstract

Both enantiomers of 2α,4-dihydroxy-1,8-cineole (2) have been synthesized. The enantiomer present in possum urine is the (―)-(1R,2R,4R)-isomer (2'). This diol is biosynthesized in the possum from (1R,2R,4S)-2α-hydroxy-1,8-cineole (18).