Synthesis and X-Ray Crystal Structure of 8,9-Dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahydropyrrolo[2,1-α]isoquinolinium Iodide

Abstract

N-Methylation of 6,7-dimethoxy-1-(2¿-phenylcyclopropyl)-3,4-dihydroisoquinoline (3b) with iodomethane in refluxing acetone gave the modified Cloke rearrangement product, 8,9-dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahyropyrrolo[2,1-a] isoquinolinium iodide (5b), a new derivative of the pyrrolo [2,1-a] isoquinoline skeleton, together with the methiodide salt (4b) of (3b). The structure of (5b) was confirmed by X-ray crystallographic analysis.