Studies of Australian Ascidians. II. Novel Cytotoxic Iodotyrosine-Based Alkaloids From Colonial Ascidians, Aplidium sp

Abstract

Samples of colonial ascidians, Aplidium sp., have yielded three novel iodinated L-tyrosine alkaloids (1)-(3). The structures of these compounds were delineated on the basis of one and two-dimensional n.m.r. experiments at 300 MHz, and confirmed by the total synthesis of one of them (2).